Four new species of Baccharis are described from western Mexico and one is raised in rank from variety. Baccharis charucoensis Nesom, sp. nov., from the Rio Mayo region along Chihuahua-Sonora border, is similar in habit and related to B. macrocephala of eastern Mexico but differs in its linear leaves with stiffly ciliate margins. Baccharis horizontalis Nesom, sp. nov., from western Durango and adjacent Sinaloa, is similar and closely related to the widespread B. serrifolia but differs in its sessile leaves and distant geographical location. Baccharis supplex Nesom, sp. nov., from southeastern Durango (mpios. Mezquital and Súchil) differs from the sympatric B. thesioides in its rhizomatous habit with one or few stems from the base, broader leaves, and few-flowered capitulescence. Baccharis praetermissia Nesom, sp. nov., from the Cape Region of Baja California Sur, is distinct in its erect habit, nearly glabrous stems, glabrous, elliptic leaves, dense capitulescence, and non-accrescent pappus, and disjunct geography within sect. Aristidentes. Baccharis multiflora var. herbacea McVaugh from western Michoacan is recognized here at specific rank: Baccharis herbacea (McVaugh) Nesom, comb. et stat. nov. Each of these five species apparently is rare.